FLStudio 20.5
PreSonus Audiobox USB96 interface
Various plugins (FlStudio, Klanghelm, Soundtoys, U-He, Sonalksis)
With my 2011 Macbook Pro i never had this issue. I don't have this issue when i'm using another program like Reaper ...
FLStudio, with an XLR cable in the microphone input on the sound card and my headphones on the headphone output on the sound card.
I hit the sound card with the guitar and the cable popped out from the computer ...